I know why would you do this, because I can never sleep on the plane, and Bonine or Antivert if I am not mistake are nondrowsy antihestimines. So is there a drug interaction with taking Bonine and Tylenol PM?
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3 comments ↓
I wouldn’t combine two pills that can cause drowsiness.
Just buy the regular dramamine (look at the packaging, there’s two different version) that causes drowsiness. That will also help with the motion sickness and allow you to sleep as well.
As for your specific interaction question with Bonine & Tylenol PM:
Interactions between your selected drugs
Moderate Drug-Drug Interaction diphenhydrAMINE (Ingredient of Tylenol PM) and Bonine (meclizine) (Moderate Drug-Drug)
MONITOR: Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. Use of neuroleptics in combination with other neuroleptics or anticholinergic agents may increase the risk of tardive dyskinesia.
MANAGEMENT: Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A reduction in anticholinergic dosages may be necessary if excessive adverse effects develop.
Bonine is also an antihistamine and drowsiness is listed as a common side effect. The active ingredient in Tylenol PM is diphehydramine, which is the generic name for Benadryl. Since they’re both antihistamines, you may not want to take them together.
You can always call and talk to a pharmacist just to make sure though.
bonine and antivert both contain meclizine which may cause drowsiness
but not as much as diphenhydramine which is found in tylenol PM.
taking meclizine with tylenol PM would cause increased drowsiness
with possible hangover effect in the morning. be sure to take
the meclizine BEFORE you get motion sickness (1-2 hrs before the flight). dramamine contains a form of diphenhydramine. it would
prevent motion sickness and help you sleep.
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